Efficacy of Epidural Steroid in Controlling Postoperative Pain After Primary Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial
Overview
- Phase
- Phase 4
- Intervention
- epidural lidocaine
- Conditions
- Postoperative Pain
- Sponsor
- Thammasat University
- Enrollment
- 108
- Locations
- 1
- Primary Endpoint
- post-operative pain
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to determine efficacy of epidural steroid for postoperative pain control after TKA
Detailed Description
Epidural triamsinolone can reduce postoperative pain and longer duration of pain control after TKA
Investigators
Supakit Kanitnate
orthopaedic department
Thammasat University
Eligibility Criteria
Inclusion Criteria
- •osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty
- •50-85 years old
- •ASA class 1-3
Exclusion Criteria
- •unable to perform epidural anaesthesia
- •history of drug allergies: lidocaine, steroid
- •renal impairment (CrCl \<30 mL/min)
- •liver impairment
- •cognitive function disorders
- •displacement of epidural catheter
Arms & Interventions
Epidural lidocaine
epidural lidocaine: 3 mL of 1% lidocaine with adrenaline and 3 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery
Intervention: epidural lidocaine
epidural triamsinolone
epidural triamsinolone: 40 mg of triamsinolone (1 mL), 2.5 mL of 1% lidocaine with adrenaline and 2.5 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery
Intervention: epidural triamsinolone
Outcomes
Primary Outcomes
post-operative pain
Time Frame: 3 months
measured with VAS for pain (VAS at rest and on motion)
Secondary Outcomes
- functional knee score(3 months)