Influence of support on intra-abdominal pressure, hepatic kinetics of indocyanine green and extravascular lung water during Prone Positioning (PP) in ARDS patients: a randomised crossover study
Completed
- Conditions
- RespiratoryRespiratory disordersAcute Respiratory Distress Syndrome (ARDS)
- Registration Number
- ISRCTN67999735
- Lead Sponsor
- Sainte Marguerite Hospital (France)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Twenty consecutive patients with ARDS were included and turned prone in the medical intensive care unit of Sainte Marguerite University Hospital in Marseille, France. Patients were prospectively included in this study after obtaining written informed consent from the next of kin. The study design was approved by the Comité Consultatif de Protection des Personnes dans la Recherche Biomédicale of Marseille. ARDS was defined in accordance with the recommendations of the American/European Consensus Conference.
Exclusion Criteria
Patients with unstable cardiovascular function, cerebral injury or unstable spinal fractures, patients subjected to major abdominal surgery and patients with a history of neuromuscular disease were excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Intra-Abdominal Pressure (IAP)<br>2. Plasma Disappearance Rate of Indocyanine Green (PDRICG)<br>3. Extravascular Lung Water (EVLW)<br>4. Partial Pressure of Oxygen in Arterial Blood (PaO2)/Fraction of Inspired Oxygen (FiO2) ratio<br>5. Central Venous Pressure (CVP)<br>6. Mean pulmonary arterial pressure<br>7. Pulmonary artery occlusion pressure
- Secondary Outcome Measures
Name Time Method o secondary outcome measures