Comparison of ultrasound guided subcostal transverse abdominis plane block using dexamethasone and clonidine as adjuvants with ropivacaine for postoperative analgesia in laparoscopic surgeries: A prospective randomized double blind study
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- 1. To compare the duration of analgesic effect by addition of dexamethasone and clonidine with ropivacaine in sub costal TAP block
研究概览
简要总结
Regional anaesthesia is one of popular methods and has become integral part of both intraoperative anaesthesia and post-operative analgesia.
Wide variety of blocks is being practiced, which avoids polypharmacy, reduces hospital stay and provide good post-operative recovery to the patients.
One such modality which aims at smooth post-op recovery in laparoscopic surgeries is subcostal transverse abdominis plane (TAP) block.
The better outcome of the subcostal TAP block is due to accurate localization of transverse abdominis plane by ultrasound guidance and prolongation of duration of action with help of adjuvants like fentanyl, dexamethasone, clonidine etc. to local anaesthetics.
This study aims to compare the effect of drugs dexamethasone and clonidine as adjuvant to ropivacaine in subcostal TAP block to decrease post-operative pain and to ease the recovery in patients undergoing laparoscopic abdominal surgeries
In this study patients will be randomly allocated in two groups and recieve TAP block at the end of surgery
Group D: Patients in this group will receive TAP block on each side with 0.375% ropivacaine 20 ml along with 1ml (4mg) of dexamethasone as additive
Group C: Patients in this group will receive TAP block on each side with 0.375% ropivacaine 20 ml along with 1mcg/kg of clonidine made to 1ml.
Postoperatively we assess the duration of analgesic effect by addition of dexamethasone and clonidine with ropivacaine in sub costal TAP block. To determine VAS scores in first 24 h. Secondary, Objectives:- 1. To assess incidence of nausea or vomiting or other side effects, if any.
The time at which rescue analgesia administered will be noted. Side effects like bradycardia, hypotension will be monitored and treated as per standard care.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing elective laparoscopic abdominal surgeries of duration 60-120 mins ASA Physical status 1,2 Those who willing to participate.
排除标准
- •Patient refusal.
- •Patients with ASA III and IV.
- •Patients with BMI < 18 kg/m2 and > 35 kg/m
- •Local infection at the site of block.
- •Allergy to study medications.
- •6.Chronic use of pain medications.
结局指标
主要结局
1. To compare the duration of analgesic effect by addition of dexamethasone and clonidine with ropivacaine in sub costal TAP block
时间窗: 24 hrs
2. To determine VAS scores in first 24 h.
时间窗: 24 hrs
次要结局
- To assess incidence of nausea or vomiting or other side effects, if any.(24 hrs)