Fetuin-A as a Marker in Obesity and Type 2 Diabetes Mellitus
- Conditions
- Diabete Type 2
- Registration Number
- NCT04218305
- Lead Sponsor
- Minia University
- Brief Summary
The aim of this study is to assess the significance of serum fetuin-A as a marker of obesity and type 2 diabetes mellitus. We used multiple statistical approaches to determine that the fetuin-A level is correlated to body mass index (BMI) as well as random blood sugar in type 2 diabetic patients. Also, we found that there is a Positive correlation between the serum fetuin-A levels and the level of glycosylated hemoglobin (HbA1c) in diabetic patients.
- Detailed Description
The study was a case-control study. We started the study to be performed on eighty subjects divided into four groups:
The first group: include twenty subjects with type 2 diabetes mellitus The second group: include twenty obese subjects whose body mass index is 30 or over The third group: include twenty obese subjects with type 2 diabetes mellitus The fourth group includes twenty apparently healthy subjects as control.
In this study, we concluded that:
1. Serum fetuin-A can be used as a biomarker and independent risk factor and marker for diagnosis of DM and DM has a detrimental effect on serum fetuin-A fetuin-A could be of relevance for the development of insulin resistance
2. Higher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance
3. Increased serum fetuin-A levels constitute an independent marker of lipid profile.
4. fetuin-A may play a role in the pathogenesis of T2DM.
5. The inhibition of insulin receptor by fetuin-A may lead to increased lipolysis and efflux of free fatty acids from adipose tissue. This could explain associated dyslipidemia observed in type 2 diabetic patients in the present study.
Finally, our finding that high plasma fetuin-A levels predict the incidence of type 2 diabetes independently of other established risk factors supports the hypothesis that fetuin-A may play a role in the development of type 2 diabetes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 400
- • The study included obese and type 2 diabetic patients aged 45-60 years old. and control healthy adult persons
-
• Cardiac disease and Hypertensive disease
- Respiratory disease
- Renal disease
- GIT and Liver disease
- Rheumatologic disease
- Blood disease
- Endocrine disease except for type 2 diabetes mellitus
- All with a specific therapeutic drug history.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1- Study of human serum fetuin-A and whether it is involved in insulin resistance Baesline 2- To assess the significance of serum fetuin-A as a marker in obesity and type 2 diabetes mellitus
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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