Postspinal Hypotension and Cardiac Performance in the Elderly

Completed

• Conditions: ARTHROPLASTY, REPLACEMENT; ANESTHESIA

• Registration Number: NCT02978066
• Lead Sponsor: Karolinska Institutet

Brief Summary

Patients, scheduled for elective arthroplasty were monitored with Lithium Dilution Cardiac Output monitor (LiDCOplus™) before and 45 minutes after spinal anesthesia. Hypotension was defined as systolic blood pressure ≤ 100 mmHg or ≥ 30% decrease from baseline. Associations between hypotension and the hemodynamic changes after preanaesthetic fluid loading and spinal anesthesia were analysed by logistic regression analyses.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Study Start: 2012-12
• Primary Completion: 2014-04
• Study Completion: 2014-04
• Study First Submitted: 2016-11-28
• Study First Submitted QC: 2016-11-28
• Study First Posted: 2016-11-30
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-16
• Last Update Posted: 2020-09-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• hip or knee arthroplasty
• spinal anaesthesia
• age 65 years or more

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Exclusion Criteria

• weight <40kg
• concomitant lithium medication
• written informed consent not obtained
• research team unavailable

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stroke volume in ml	0-45 minutes after spinal anaesthesia	the blood volume pumped by the heart at each stroke

Secondary Outcome Measures

Name	Time	Method
Arterial blood pressure mmHg and change from baseline	0-45 minutes after spinal anaesthesia	mmHg measured by arterial catheter