Temozolomide in Treating Patients With Recurrent Oligodendroglial Tumors
- Conditions
- Brain and Central Nervous System Tumors
- Registration Number
- NCT00003731
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of temozolomide in treating patients with recurrent oligodendroglial tumors.
- Detailed Description
OBJECTIVES: I. Assess the therapeutic activity of temozolomide as first line chemotherapy in patients with recurrent oligodendroglial tumors after radiation therapy. II. Assess the objective response and duration of response of these patients given this treatment. III. Characterize the acute side effects of temozolomide in this patient population.
OUTLINE: This is an open label, multicenter study. Patients receive oral temozolomide on days 1-5. Courses are repeated every 28 days. Treatment continues for a maximum of 12 courses in the absence of unacceptable toxicity or disease progression. Patients are followed every 3 months until disease progression.
PROJECTED ACCRUAL: A total of 15-33 patients will be accrued for this study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 39
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (24)
Institut Gustave Roussy
🇫🇷Villejuif, France
U.Z. Gasthuisberg
🇧🇪Leuven, Belgium
Academisch Ziekenhuis Utrecht
🇳🇱Utrecht, Netherlands
Instituto Portugues de Oncologia de Francisco Gentil
🇵🇹Lisbon, Portugal
Academisch Ziekenhuis der Vrije Universiteit Brussel
🇧🇪Brussels, Belgium
Kantonspital Aarau
🇨ðŸ‡Aarau, Switzerland
Centre Hospitalier Universitaire Vaudois
🇨ðŸ‡Lausanne, Switzerland
CHU de la Timone
🇫🇷Marseille, France
Hopital Universitaire Erasme
🇧🇪Brussels, Belgium
Centre Hospitalier Regional de Lille
🇫🇷Lille, France
CHU de Nancy - Hopital Neurologique
🇫🇷Nancy, France
Centre Antoine Lacassagne
🇫🇷Nice, France
Hopital Pasteur
🇫🇷Nice, France
Nervenklinik Bamberg
🇩🇪Bamberg, Germany
Klinikum der Universitat Regensburg
🇩🇪Regensburg, Germany
Universitaetsklinikum Benjamin Franklin
🇩🇪Berlin, Germany
Azienda Ospedaliera di Padova
🇮🇹Padova (Padua), Italy
Istituti Fisioterapici Ospitalieri - Roma
🇮🇹Rome, Italy
University Medical Center Nijmegen
🇳🇱Nijmegen, Netherlands
Rotterdam Cancer Institute
🇳🇱Rotterdam, Netherlands
Postgraduate Medical Institute
🇸🇰Bratislava, Slovakia
Inselspital, Bern
🇨ðŸ‡Bern, Switzerland
University Hospital
🇨ðŸ‡Basel, Switzerland
Western General Hospital
🇬🇧Edinburgh, Scotland, United Kingdom