NCT01888549已完成不适用
Efficacy of Proton Pump Inhibitor for Chronic Cough Caused by Gastroesophageal Reflux; Double-blind, Placebo-controlled, Randomized Clinical Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- change in LCQ score and cough VAS, comparing PPI-treated group to placebo
研究概览
简要总结
Efficacy of proton pump inhibitor for chronic cough caused by gastroesophageal reflux; double-blind, placebo-controlled, randomized clinical trial
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ages of 18 and 70 years had chronic cough of >8 weeks in duration
排除标准
- •abnormal chest X ray, PNS view
- •previous surgical or endoscopic antireflux procedure
- •previous aerodigestive malignancy or Barrett's oesophagus
- •current smokers or ex-smok-ers (defined as those who quit smoking <3 months prior to study enrolment or those who have quit, but have a 20 pack year smoking history)
- •Malignancy History (lung cancer, esophageal cancer etc.)
- •upper respiratory infection within 8 weeks of study enrolment
- •currently using a PPI, H2 blocker, beta-blocker, angiotensin-converting enzyme inhibitor, corticosteroid, methylxanthine, inhaled beta-agonist, anti-inflammatory agent or anticholinesterase drug at time of enrolment
研究组 & 干预措施
arm1-High dose PPI
Experimental
干预措施: High-dose PPI (Drug)
arm2-standard dose PPI
Active Comparator
干预措施: standard PPI (Drug)
arm3-placebo
Placebo Comparator
Esomeprazole placebo
干预措施: placebo (Drug)
结局指标
主要结局
change in LCQ score and cough VAS, comparing PPI-treated group to placebo
时间窗: change in LCQ score after 4 weeks and 8 weeks
次要结局
- change in LCQ score and cough VAS, comparing PPI-treated group to placebo(change in cough VAS after 4weeks and 8 weeks)
研究者
研究点 (1)
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