Impact of Prokinetic Use After Emergency Intestinal Anastomosis on Postoperative Clinical Outcomes

Not Applicable

• Conditions: Prokinetic Use After Emergency Intestinal Anastomosis
• Interventions: Drug: Prokinetic Motility Agents as primpiram and gastreg

• Registration Number: NCT05290753
• Lead Sponsor: Sohag University

Brief Summary

Prokinetic drugs used to accelerate healing of intestinal anastomosis of urgent cases which not prepared preoperative by increase intestinal motility and gastric emptying and decrease postoperative adhesions They are many types of prokinetics as cholinergic agonists, dopamine antagonist, serotonergic agonists and macrolides Agents of prokinetics administered immediately post operation and at the time of hospitalization

Detailed Description

By evaluation the effect of prokinetic use versus non use after emergency intestinal intestinal anastomosis on short and long term clinical outcome It will be prospective cohort study which conducted in sohag university hospital Study will include patients presented with urgent anastomosis Inclusion criteria: all adults underwent emergency intestinal anastomosis Exclusion criteria: pediatrics, patients with comorbidities and patients with electively resection and anastomosis.

Primary goals are to detect effect of prokinetics on incidence of leakage rate Secondary outcomes include early bowel opening, enteral feeding, post operative pain, wound infection and adhesion formation rate.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2022-01-01
• Study First Submitted: 2022-03-04
• Study First Submitted QC: 2022-03-19
• Study First Posted: 2022-03-22
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-30
• Last Update Posted: 2022-05-03
• Primary Completion: 2022-06-01
• Study Completion: 2022-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• all adult patients

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Exclusion Criteria

• pediatrics
• patients associated with comorbidities
• patients with electively resection and anastomosis

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Prokinetic use in accelerate healing of urgent intestinal anastomosis	Prokinetic Motility Agents as primpiram and gastreg	Prikinetic agents administered immediately post operative and time of stay at hospital twice daily

Primary Outcome Measures

Name	Time	Method
Leakage rate	5 days postoperative	Fecal fistula

Secondary Outcome Measures

Name	Time	Method
Early bowel opening	3 days postoperative	Duration taken to patient to pass feces and flatus

Trial Locations

Locations (1)

Of medicine, Sohag university hospital; 🇪🇬 Sohag, Egypt