Role of ASL non contrast perfusion MRI in evaluation of patients with epilepsy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Peri-ictal /interictal perfusion changes and their localisation - Hyperperfusion/Hypoperfusion
研究概览
简要总结
Consecutive patients with neocortical epilepsy who have undergone EEG monitoring and are referred to the Department of Radiodiagnosis and Imaging to undergo MRI
imaging according to the standard epilepsy protocol will be included.
A single post labelling delay (PLD) pseudocontinuous-ASL (PCASL) sequence will be included in the MRI studies – generating CBF maps in grayscale and colour. Areas of altered perfusion on ASL will be identified. Using manually drawn region of interests asymmetry indices will be calculated.
Regional cerebral blood flow maps will be compared with the EZ determined by the
other tests and the strength of concordance will be assessed using Kappa coefficient.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 0.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with suspected or diagnosed epilepsy who have undergone or will undergo EEG monitoring and have been referred for Brain MR imaging.
排除标准
- •General contraindications to MR neuro-imaging such as cardiac pacemakers, implantable defibrillators.
结局指标
主要结局
Peri-ictal /interictal perfusion changes and their localisation - Hyperperfusion/Hypoperfusion
时间窗: AT baseline. Immediately after acquisition and post processing of ASL-MRI sequence is complete.
次要结局
- Agreement between ASL sMRI & EEG seizure zone localisation.(Once patient undergoes the above mentioned investigations MRI ASL & EEG. Usually on the same day.)
研究者
Shaurya Khanduri
Kasturba Medical College , Manipal