Investigating the neurobiological stress response to pain in Adolescent Non-Suicidal Self-Injury

Not Applicable

• Conditions: on-Suicidal Self-Injury; F60.3; Emotionally unstable personality disorder

• Registration Number: DRKS00007807
• Lead Sponsor: Klinik für Kinder- und Jugendpsychiatrie, Zentrum für Psychsoziale Medizin, Universitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02-13
• Study Completion: 2016-07-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

adolescents with non-suicidal self-injur/ borderline personality disorder; age and sex matched healthy controls

Exclusion Criteria

Other major psychiatric disorders (e.g.schizophrenia), current episode of substance abuse, cardiovascular disease (e.g. hypertension)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hypothalamic–Pituitary–Adrenal (HPA) axis assessed by saliva cortisol pre and post painful stimulation;<br>autonomic nervous system response continuously assessed by heart rate and heart rate variability and blood pressure pre and post painful stimulation

Secondary Outcome Measures

Name	Time	Method
The latencies to the first pain sensation (pain threshold) and to intolerable pain (pain tolerance) are measured with a stopwatch in seconds; pain intensity ratings are obtained using visual analogue scales and standardized questionnaires