NL-OMON55900RecruitingNot Applicable
The UPDATE trial (Uvb Phototherapy in Dermatology for ATopic Eczema): A multicenter randomized controlled trial of narrowband UVB versus optimized topical therapy in patients with atopic eczema. - UPDATE trial
Amsterdam UMC0 sites316 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 316
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •- Adult (>=18 years of age) patient meeting the UK working party criteria for
- •atopic eczema;
- •- AE insufficiently controlled by standard topical care and therefore eligible
- •for NB-UVB or OTT;
- •- Investigator Global Assessment (IGA, 0-4) of >= 2 (moderate disease);
- •- Eczema Area and Severity Index (EASI) of >= 7 (moderate disease);
- •- Understood and voluntarily signed and dated an informed consent form prior to
- •any study-related procedure or has a legal representative who has, and is
- •willing to comply with the study*s requirements.
Exclusion Criteria
- •- Contra-indication for NB-UVB;
- •o Genetic defects associated with photosensitivity or skin cancer;
- •o Heavily photo-damaged skin;
- •o History of multiple (>1) skin malignancies;
- •o Use of systemic immunosuppressants/immunomodulators;
- •o Use of medication associated with photosensitivity;
- •- Patient is already on systemic AE therapy;
- •- Patient is already on OTT in the past 2 months;
- •- NB-UVB or any systemic therapy in the past 9 months.
Investigators
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