Women Health Cohort for Breast, Bone and Coronary Artery Disease

Completed

• Conditions: Coronary Artery Disease

• Registration Number: NCT03235622
• Lead Sponsor: Seoul National University Hospital

Brief Summary

A single center cohort which enrolled women who performed mammography, bone densitometry (DEXA), and coronary CT angiography in Seoul National University Bundang Hospital from March 2011 to February 2013.

Detailed Description

To evaluate whether bone mineral density and breast arterial calcification can predict coronary artery disease in women older than 40 years

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2013-02
• Status Verified: 2017-07
• Study Completion: 2017-07
• Study First Submitted: 2017-07-24
• Study First Submitted QC: 2017-07-29
• Last Update Submitted: 2017-07-29
• Study First Posted: 2017-08-01
• Last Update Posted: 2017-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 2100

Inclusion Criteria

• Women (≥ 40 years) who performed mammography, bone DEXA, and coronary CT angiography at health promotion center of Seoul National University Bundang Hospital.

Exclusion Criteria

• Women who have history of breast surgery or intervention
• Women who have history of myocardial infarction or revascularization
• Too poor image quality of coronary CT angiography for interpretation
• Renal dysfunction with serum creatinine ≥ 1.4mg/dL

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of coronary plaque	5 years	Any coronary plaque in coronary CT angiography

Secondary Outcome Measures

Name	Time	Method
Characteristics of coronary plaque	5 years	Plaque characteristics (fibrosis, calcification, lipid, thrombosis) in coronary CT angiography
Major adverse cardiovascular events	5 years	Cardiac death, nonfatal myocardial infarction, ischemic stroke, coronary revascularization