A study comparing the impact of prophylactic infusion of two different doses of phenylephrine on maternal hypotension and outcome of newborns in females undergoing cesarean section under spinal anaesthesia.

Not Applicable

Conditions: Health Condition 1: O746- Other complications of spinal andepidural anesthesia during labor and delivery

Recruitment & Eligibility

Inclusion Criteria

1.Patients with physical status ASA grade I or II.

2.All patients giving written informed consent.

3.Patients with gestation age > 36 weeks posted for elective caesarean delivery under spinal anaesthesia.

4.Patients belonging to age group of 18 to 35 years.

Exclusion Criteria

1.Parturients with complications like risk of excessive bleeding (placenta previa, prolonged labor, abnormal presentation, multiple gestation)

2.Patients with pre-existing or pregnancy induced hypertension or maternal SBP < 100mm Hg.

3.Patients with cardiovascular disease, cerebrovascular disease, severe anemia or diabetes.

4.Patients with known fetal abnormalities.

5.Patients with contraindication to spinal anaesthesia.

6.Patients with known allergy to phenylephrine

7.Patients with inability or refusal to give informed consent

Primary Outcome Measures

Name	Time	Method
To assess the effect of prophylactic administration of two different infusion rates of phenylephrine (25 and 50 micrograms/minute) on maternal hemodynamics and neonatal outcomes in parturients undergoing caesarean section under spinal anaesthesia. <br/ ><br>-To assess the changes in maternal blood pressure <br/ ><br>-To assess the changes in maternal heart rate. <br/ ><br>Timepoint: From administration of spinal anaesthesia intraoperstively till the end of the surgery.

Secondary Outcome Measures

Name	Time	Method
To assess the effect of prophylactic administration of two different infusion rates of phenylephrine (25 and 50â?¢ micrograms/minute) on maternal hemodynamics and neonatal outcomes in parturients undergoing caesarean section under spinal anaesthesia. <br/ ><br>â?¢To assess the incidence of nausea and vomiting <br/ ><br>â?¢To assess the fetal outcomes in terms of APGAR score and acidosis. <br/ ><br>Timepoint: From administration of spinal anaesthesia intraoperstively till the end of the surgery.