The Role of Microbiota in Pancreatic Cancer and Precursor Lesions
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Composition of microbiota in pancreatic cancer
研究概览
简要总结
This is a prospective observational study aiming to investigate the microbiome in patients suspected of having pancreatic cancer. The purpose is to enhance diagnostic accuracy by developing screening protocols for high-risk individuals, identifying specific microbial biomarkers, and improving prognostic criteria to optimize treatment response.
Participants will be asked to complete a questionnaire, provide oral and fecal swabs, and-if clinically indicated-1-2 pancreatic biopsies will be collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with a suspected lesion (solid/cystic) in the pancreas undergoing diagnostic or therapeutic endoscopic procedure
- •Age of 18 years or above
- •Signed informed consent form
排除标准
- •Contraindications for endoscopic or surgical procedure, such as uncorrected coagulopathy
结局指标
主要结局
Composition of microbiota in pancreatic cancer
时间窗: 2037
To examine the composition of microbiota in pancreatic cancer and its precursors, to explore association between bacterial/fungal genera and final diagnosis, survival and risk of recurrence, but also to examine a possible role of microbiota in development of surgical adverse events.
次要结局
- Databank(2037)
- Biobank(2037)
- Intratumor and gut mikrobiota(2037)
- Intratumor viral DNA(2037)
- Microbiome-tumor interaction(2037)
- Microbiome composition(2037)