Dose high dose remifentanil induce postoperative hyperalgesia?
Not Applicable
- Conditions
- postoperative pain
- Registration Number
- JPRN-UMIN000016426
- Lead Sponsor
- Dept. of dental anesthesia and pain management, Tohoku Univ. Hosp.
- Brief Summary
Remifentanil is associated with acute opioid tolerance that can lead to increased postoperative consumption of opioid analgesics. The purpose of this study was to determine whether a low dose of ketamine prevents remifentanil-induced acute opioid tolerance and affects the neutrophil-lymphocyte ratio (NLR), a newly recognized biomarker of in ambition. High-dose intraoperative remifentanil induced postoperative acute opioid tolerance that was prevented by infusion of low-dose ketamine. Ketamine increased the postoperative NLR associated with decreased fentanyl requirement for postoperative pain control.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Not provided
Exclusion Criteria
intracranial hypertension taking pain killer mental disease alcoholism
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visual analogue pain scale Amount of supplemental anesthetics Side effects of anesthetics
- Secondary Outcome Measures
Name Time Method