Supplementary Oxygen in Surgical and Medical Wards in the Capital Region of Denmark Evaluated by 30-day Mortality, a Retrospective Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Oxygen gas
- Conditions
- Oxygen Toxicity
- Sponsor
- Hannibal Troensegaard
- Enrollment
- 11196
- Locations
- 1
- Primary Endpoint
- 30- day mortality
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This study evaluates the use and effects of supplementary oxygen in surgical and medical wards on patients admitted to a hospital in the capital region of Denmark. The population will be divided in to three groups according to their oxygenation status. The main outcome will be 30-day mortality, with secondary outcomes being Length of stay, 30-day admission to ICU, 30-day reoperations, 30-day readmission, and peak values within 30-days of C-reactive protein, S-Creatinine, Troponin.
Investigators
Hannibal Troensegaard
Primary investigator
University Hospital Bispebjerg and Frederiksberg
Eligibility Criteria
Inclusion Criteria
- •Admission date between 1st of January 2014 to 29th of December 2014 on a hospital in the capital region of Denmark
- •Unique (first) admission in database for either:
- •Hip fracture requiring surgery
- •Chronic obstructive pulmonary disease in exacerbation
- •Acute mycardial infarction
- •Open abdominal surgery
Exclusion Criteria
- •No data on saturation within 48 hours after
- •Admission (Medical patients)
- •Discharge from the post anaesthesia care unit (Surgical patients)
- •No data on primary outcome (30-day mortality)
Arms & Interventions
Hypoxia
Patients without chronic obstructive pulmonary disease: blood oxygen saturation \<94 % irrespective of supplemental oxygen Patients with chronic obstructive pulmonary disease: blood oxygen saturation \<88% irrespective of supplemental oxygen
Intervention: Oxygen gas
Normoxia
Patients without chronic obstructive pulmonary disease: blood oxygen saturation 94-98% in combination with supplemental oxygen OR blood oxygen saturation ≥94% without supplemental oxygen. Patients with chronic obstructive pulmonary disease: blood oxygen saturation 88-92% in combination with supplemental oxygen OR blood oxygen saturation ≥88% without supplemental oxygen.
Intervention: Oxygen gas
Hyperoxia
Patients without chronic obstructive pulmonary disease: blood oxygen saturation \>98% in combination with supplemental oxygen Patients with chronic obstructive pulmonary disease: blood oxygen saturation \>92% in combination with supplemental oxygen
Intervention: Oxygen gas
Outcomes
Primary Outcomes
30- day mortality
Time Frame: 30 days
Will be reported as a fraction of positives within the exposure group population
Secondary Outcomes
- 30- day readmission(30 days)
- Organ markers in blood samples(30 days)
- 30- day admission to ICU(30 days)
- Length of stay(30 days)