Electrochemistry Measurement of Skin Hydration Parameters

Not Applicable

• Conditions: Acne; Atopic Dermatitis; Skin Electrochemistry
• Interventions: Other: Collects of skin's hydration

• Registration Number: NCT05071456
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

To date measuring the effect of dermocosmetic products on the main identified factors of aging and alteration of the skin barrier is based on invasive and expensive experiments. Electrochemistry enables to measure a specific signal for a substance of interest e.g. Vitamin C using an surface contact with an electrode.

Therefore, this study will evaluate the reliability and feasibility of measurements of skin's hydration parameters such as NMF and squalene using electrochemistry. These study will be made on three groups of individuals with different skin types: dry skin i.e. atopic dermatitis patients, oily skin i.e. acne skin and a control group of individual without facial dermatosis. Collects of parameters of interest will be made by using patch using electrochemistry (contact with an electrode and potentiostat to detect an electric signal) . It is a simple method that relies on a sensor / electrode pair that allows a study of the surface molecules of the skin. Application in the measurement of vitamin C in food products has already been validated.

On a second hand, a collect by chromatography of the parameters of interest will be carried out in order to compare the new method with the reference method.

This procedure has been developed via a procedure including collecting surface parameters using a patch an developping special electrodes and miniaturized detecting signal tool (potentiostat)

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-09
• Study First Submitted: 2021-09-09
• Study First Submitted QC: 2021-09-27
• Study First Posted: 2021-10-08
• Study Start: 2021-10-15
• Last Update Submitted: 2021-10-15
• Last Update Posted: 2021-10-18
• Primary Completion: 2021-12-16
• Study Completion: 2021-12-16

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 18 ≤ Age ≤ 70
• Subjects with past history or follow-up for acne or rosacea stage I ou II, atopic dermatitis mild to moderate without immunosuppressive treatment
• Subjects enabling to perform a one day visit at the hospital
• Written consent according to local regulatory requirements
• Affiliated to a social security scheme

Exclusion Criteria

• Pregnant women or breastfeeding
• Patient under guardianship or curatorship, legal protection or protection of justice
• Participation in other interventional research on skin moisturizer

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group of patient without facial dermatosis	Collects of skin's hydration	-
Atopic dermatitis patients	Collects of skin's hydration	-
Patient with oily acne skin	Collects of skin's hydration	-

Primary Outcome Measures

Name	Time	Method
Feasibility of collecting an electrochemical measure of skin hydration parameter (natural moisturizer factor electric signal) at two different sites of the face at T0 using patch and electrode	Day 0 or Day 1	Feasibility of collecting an electrochemical measure of skin hydration parameter (natural moisturizer factor electric signal) at two different sites of the face at T0 using patch and electrode. Signal detection (mVolt) or not using a patch to collect skin surface parameter applied on an electrode to collect and electric signal.

Secondary Outcome Measures

Name	Time	Method
Validation of the measure process for different skin type e.g: dry, oily, normal	Day 0 or Day 1	Rate of failure by site or skin type, obtained measure mean and SD for all and regarding each group
Determine the correlation between electrochemistry measures or skin hydration (level of electrical signal mvolt ) and reference method: corneometry or chromatography.	Day 0 or Day 1	Those two methods are routinely used to asses skin hydration using a swab contact then migration in a chromatography column or use of sebumeter Correlation coefficient between level of electrochemical measure (signal) regarding skin types and measures issued from reference methodology (corneometry or chromatography)
Describe individuals' habits or daily routine for skin care using a questionnairemethodology (corneometry or chromatography)	Day 0 or Day 1	Descriptive statistics: smoke, sun exposure, moisturizer use

Trial Locations

Locations (1)

Assistance Publique Hôpitaux de Paris - CHU Henri Mondor; 🇫🇷 Créteil, France