Temporal analysis of Diastolic Shock Index in patients with Septic Shock and its correlation with clinical outcomes in Indian setting- a prospective observational study.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 97
- Locations
- 1
- Primary Endpoint
- Mortality outcome in ICU
Study Overview
Brief Summary
Summary: Septic shock at the end of continuous spectrum of sepsis, is a life threatening condition accounting for high mortality in patients getting admitted in intensive care units. Early detection and prompt intervention is one of the goals of effective therapy in management of septic shock.
Diastolic blood pressure, the minimum pressure in the aorta that is during the diastolic period of the cardiac cycle. Diastolic shock index has been implicated as a surrogate to the state of the vascular tone. Ospina tascón et al in 2020 studied the diastolic shock index and its clinical outcomes in septic shock patients. They concluded that DSI can serve as an early indicator of high mortality risk in septic shock patients. Prospective studies regarding diastolic shock index and its correlation to clinical outcomes are lacking. So in this prospective observational study on adult septic shock
patients, we aim to analyze the temporal trends of Diastolic Shock Index and its correlation with clinical outcomes. We will also compare the other hemodynamic indices such as shock index, modified shock index, lactate, VIS score and their prognostic performance.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 90.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients above the age of 18 years Diagnosed with septic shock according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Patients/ guardians giving informed and written consent for the same.
Exclusion Criteria
- •Pregnant women Shock caused due to other causes Acute/ chronic atrial fibrillation, presence of ventricular arrhythmia, use of definitive/transitory pacemaker, presence of valvular heart disease Recordings from intra-arterial catheter placed at sites other than radial and femoral artery Patients/guardians refusing consent.
Outcomes
Primary Outcomes
Mortality outcome in ICU
Time Frame: 28 days
Secondary Outcomes
- Correlation with ICU severity scores(Number of vasopressor free days)
Investigators
Dr Afzal Azim
Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow