Discovering Risk Factors for Cardiovascular Diseases in Elderly Asthma
试验速览
- 阶段
- 不适用
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- coronary calcium score
研究概览
简要总结
This study is a cross-sectional study to evaluate the relationship between coronary calcium score and clinical parameters of asthma such as onset of disease, lung function parameter and airway inflammation parameter (sputum eosinophil or FeNO) in Korean elderly asthma (regardless of whether they have concomittent COPD or not) patients
详细描述
Subjects who visited Allergy Clinic in SMG-SNU Boramae Medical Center for asthma or ACO will be recruited consecutively. Subjects who meets the inclusion criteria and agree to participate in the study will take coronary artery calcium scoring CT and asthma CT (inspiration and expiration images). The correlation between the degree of coronary calcification and airway diameter, airway wall thickness, air-trapping and emphysema will be evaluated as well as clinical parameters of asthma. We will also compare those correlations from the images of healthy control subjects who performed the coronary calcium scoring CT for health checkup purpose.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •If the doctor has been diagnosed with asthma and one or more of the following criteria is met;
- •FEV1 increased more than 12% & 200 mL after 10-20 minutes of inhalation of short-acting bronchodilator (200-400 mg salbutamol)
- •Positive bronchial provocation tests (methacholine, mannitol, exercise, aspirin, etc.)
- •FEV1 Increased more than 12% & 200 mL from baseline FEV1 after anti-inflammatory treatment for 4 weeks or longer.
排除标准
- •Those who were already diagnosed and treated for coronary artery diseases.
- •Those with other structural lung diseases such as Tuberculosis destroyed lung and interstitial lung diseases
- •Those who are unable to conduct a test or questionnaire due to severe systemic illness, or cognitive dysfunction.
- •Those who are participating in other clinical trial using IND(investigational new drug) or finished other clinical trial within 30 days.
- •Those who refuse to participate in the study or withdraw the consent.
结局指标
主要结局
coronary calcium score
时间窗: through study completion, an average of 1 month
coronary calcium score from coronary calcium scoring CT which, we assumed to be a surrogate marker for cardiovascular risk.
次要结局
未报告次要终点