Hypersensitivity in eosinophilic esophagitis

Recruiting

• Conditions: Eosinophilic esophagitis

• Registration Number: NL-OMON22222
• Lead Sponsor: Amsterdam UMC, Location AMC

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 17

Inclusion Criteria

Previous diagnosis of active EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in esophageal biopsies
- Written informed consent
- Age 18-75 years

Exclusion Criteria

- Any form of treatment for EoE (topical corticosteroids, PPI or dietary treatment) in the month preceding the study
- ASA class III, IV or V
- The need for pain medication 24 hours before the visit

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measures of sensitivity of the esophagus:<br>1. Perfusion sensitivity scores in histological active disease, disease in remission and healthy controls, calculated via [(total perfusion time – lag time to perception) x maximum VAS]<br>2. Balloon pressure that induced a sensation of discomfort in histological active disease, disease in remission and healthy controls

Secondary Outcome Measures

Name	Time	Method
1. Esophageal barrier function in histological active disease and disease in remission, defined as electrical tissue impedance measured with ETIS and transepithelial electrical resistance and fluorescein flux measured in Ussing chamber<br>2. The degree of reflux in the EoE patients, as measured with 24-hours pH- impedance measurement