An observational study on Pramana Sharira and its relation with prognosis of chronic kidney disease(stage-5)
- Conditions
- Chronic kidney disease, stage 5. Ayurveda Condition: Chronic Kidney Disease (stage-5),
- Registration Number
- CTRI/2022/04/041772
- Lead Sponsor
- J S Ayurveda Mahavidyalaya
- Brief Summary
- **SUMMARY**The study entitled, “An observationalstudy on Pramana Sharira with special referenceto VishamaAyama-Vistara and its relation with prognosis of chronickidney disease (stage-5)†comprises of 6chapters namely introduction, aim and objectives, review of literature,observational study, discussion and interpretation & conclusion andsummary.
**Chapter1: Introduction**
It gives compact idea of the subject of discussion namely *PramanaSharira*. The Relevance ofthis topic especially based on its clinical importance, which was alsohighlighted.
**Chapter2: Aim and objectives**
Itgives an idea about aim & objectives of the study.
**Chapter3: Review of literature**
Review of literature is sub-divided into historical review, previous research work, review of *Pramana Sharira,* reviewof anthropometry & review of CKD – *Ayurveda* and modern perspective.Historical review consists of references pertaining to *Pramana* invarious ancient literatures of *Vedic*period, *Samhita* period and *Sangraha Kala* followedby a table with the information regarding previous research work.Review of *Pramana Sharira,* elaboratesthe details & importance of *Pramana* in various ancient ayurvedictexts, it also detailed regarding available references related to *Anguli Pramana*.Review of anthropometry dealswith details of anthropometry and its utility. *Ayurveda* and modern perspective of CKD explained in the last part of thischapter.
**Chapter-4: Observational study**
Detail methodology ofthe present study was given in this chapter along with inclusion and exclusion criteria. Afterwards observations andresults of 50 individuals of CKD (stage-5) were put forth by thetabular and graphical presentation.
**Chapter 5: Discussion and interpretation**
It is subdivided into discussion on review of literature,discussion on methodology, discussion on observation and results. It comprisesthe details of the analyzed data and comparison with the basic conceptmentioned in the ancient literature & contemporary science, also dealt withthe relevance in this era.
**Chapter 6: Conclusion and summary**
Summarizes the entire research work and it consists of conclusion drawn from the work carried outalong with further scope of research.
- **CONCLUSION***Pramana* is a crucial parameter among the *Dashavidha Pareekshyabhava* outlined in *Charaka Samhita*. As described in the *Rogabhishagjitiyam Vijnanam*, there exists a sutra that delves into the concept of “*Sama Ayama-Vistara*â€, and its direct correlation with a healthy and happy life. This historical wisdom underpins the present study, which retrospectively explores *Ayama-Vistara* disparities in CKD individuals.
§ The eGFR values, ranging from 3.7 to 13.96 ml/min. The mean eGFR was calculated at 7.64±2.61 ml/min. This data reveals significant variability in kidney function within the studied population.
§ *Ayama* (*Angula Pramana* of rhs), ranging from 71.33 to 99.54 *Angula*. The mean of *Ayama* was calculated at 88.11±6.06 *Angula. Vistara* (*Angula Pramana* of rhs), ranging from 74.89 to 99.14 *Angula*. The mean of *Vistara* was calculated at 89.62±6.46 *Angula.*
§ The difference of *Ayama-Vistara* (for rhs) ranged from 0 to 5.19 *Angula*, with a mean of 2.17±1.34 *Angula*. Which explored the difference between *Ayama* and *Vistara* measurements.
§ Results obtained from two-tailed paired t-testwas found significant at p-value <0.0001. This suggests that there are significant differences between the *Ayama* and *Vistara* measurements. The t-statistic, was calculated to be 5.188 for the values which was measured in *Angula* (rhs). These high t-statistic values further emphasize that the differences between *Ayama* and *Vistara* measurements are not due to random chance. This indicates that the subjects under the study had poor *Bala* and *Alpa* Ayu. This information is important for our research and contributes to a better understanding of the subjects we studied.
§ The Karl Pearson coefficient of correlation resulted in a correlation coefficient (r) of -0.6554. This number signified a significant negative relationship and suggests that a higher difference in *Ayama-Vistara* corresponds to lower eGFR values. The associated p-value was found to be <0.0001. This low p-value tells us that the correlation we observed is not likely due to random chance, indicating a strong statistical relationship between the difference in *Ayama-Vistara* measurements and eGFR. This relationship is particularly relevant in the context of CKD prognosis. It suggests that as the *Ayama-Vistara* difference increases, there may be a higher risk of lower eGFR values, which can be indicative of more severe kidney function issues.
§ In this study three distinct categories with 23, 22 and 5 number of individuals having differences in *Ayama* and *Vistara* measurements for assessing the prognosis of CKD with the mean score of eGFR values 9.26, 6.66 and 4.49 individuals having differences in *Ayama* and *Vistara* <2 *Angula*, 2-4 *Angula* and >4 *Angula* respectively. These findings indicating that difference in *Ayama-Vistara* is having significant negative correlation with the prognosis of CKD. So here null hypothesis is rejected and alternative hypothesis is established. This information offers clinicians a valuable tool for treatment planning and enhancing personalized patient care strategies.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
- Already diagnosed patients of chronic kidney disease (stage-5) with bad prognosis.
- (Those who have <15 ml/min eGFR or those who are under dialysis will be considered as bad prognosis) 2.
- Individuals of either sex between 30-60 years.
- Individuals with accidental or traumatic cause.
- Individuals with the history of fracture of long bone.
- 3.Individuals who had undergone amputation of limb.
- Individuals with the deformity in vertebral column.
- Any visible structural abnormalities.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The Proposed research work will help the physicians to predict the possible bad prognosis at a very early stage of the chronic kidney disease by measuring the Ayama-Vistara of the patient. Baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
P. D. Patel Ayurveda Hospital, Nadiad
🇮🇳Kheda, GUJARAT, India
P. D. Patel Ayurveda Hospital, Nadiad🇮🇳Kheda, GUJARAT, IndiaDr Mital D KananiPrincipal investigator8758072340mitalkanani11@gmail.com