Prevention of depression and poor physical function in older persons with vitamin D supplementatio

Phase 3

Completed

• Conditions: Depressieve symptomen, matige fysieke functie; depressive symptoms; poor physical function; 10047635; 10029317

• Registration Number: NL-OMON39818
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 2020-03-26
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 140

Inclusion Criteria

- age 60-80 years
- mild depressive symptoms
- at least one functional limitation
- serum 25(OH)D levels between 15 and 50 nmol/l (winter) or 15 and 70 nmol/l (summer)
- ability to comply with the study

Exclusion Criteria

- full-blown depressive disorder
- use of antidepressants
- vitamin D (more than 400 IU/day) or calcium (more than 1000 mg/day) supplementation
- major life-threatening illness
- living in an aged-people's home or nursing home

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in the CES-D score, change in physical performance score after 12<br /><br>months, change in the number of functional limitations as well as change of<br /><br>degree of functional limitations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Change in anxiety, cognition, quality of life, incidence of full-blown<br /><br>depression, timed up-and-go-test, costs.</p><br>