Examination of respiratory mechanics with trunk inclination in obese and non-obese ARDS patients

Not Applicable

Completed

• Conditions: Respiratory - Other respiratory disorders / diseases; ARDS; Diet and Nutrition - Obesity

• Registration Number: ACTRN12623000794606
• Lead Sponsor: Flinders Medical Centre

Brief Summary

In our cohort of mechanically ventilated obese patients with ARDS, supine posture provided better lung mechanics, and better CO2 clearance, without worse oxygenation, than the semi-recumbent posture. Our study highlights the importance of body habitus on postural changes in respiratory mechanics of obese ARDS patients.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2023-04-01
• Study Start: 2023-07-25
• Last Update Posted: 2 August 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

diagnosis of moderate or severe ARDS (Berlin definition), deep sedation, muscle paralysis, volume controlled mechanical ventilation

Exclusion Criteria

Not ARDS patients

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Partition respiratory mechanics -Elastance using the ventilator and the method described by Stenqvist et al (Intensive Care Med (2015) 41:1110–1113)[15-minute post intervention completion ];Partition respiratory mechanics -driving pressure using the ventilator and the method described by Stenqvist et al (Intensive Care Med (2015) 41:1110–1113)[15 minutes post intervention completion]

Secondary Outcome Measures

Name	Time	Method
Gas exchange (Arterial blood gas- PaO2)[15 minutes post intervention completion ];Gas exchange (Arterial blood gas- PaCo2)[15 minutes post intervention completion ];Gas exchange (Arterial blood gas- pH)[15 minutes post intervention completion ]