Development of a Methodology to Design a High Order Sliding Mode Controller for Drug Dosage

• Conditions: Hypertension; Diabetes; Anesthesia

• Registration Number: NCT02864212
• Lead Sponsor: Coordinación de Investigación en Salud, Mexico

Brief Summary

The aim of this observational study is to create a data base to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.

Detailed Description

The aim of this observational study is to create a database to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.

The observed drugs in this study are fast acting insulin, propofol and sodium nitroprusside.

The effect of insulin will be measured by a continuous glucose monitor, the effect of propofol by a bispectral index monitor and the the effect of sodium nitroprusside by a invasive blood pressure monitor.

Study Timeline

• Study Start: 2014-09
• Study First Submitted: 2016-07-29
• Study First Submitted QC: 2016-08-08
• Study First Posted: 2016-08-11
• Status Verified: 2020-07
• Last Update Submitted: 2020-08-05
• Last Update Posted: 2020-08-06
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• American Society of Anesthesiologists (ASA) physical status I, II, II

Exclusion Criteria

• Impossibility to measure depth of anesthesia or invasive blood pressure. Impossibility of using glucose monitor.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glucose	Every 5 minutes during 3 days.	The glucose will be measured by a continuous glucose monitor. For the group of patients for diabetes.; Note: This protocol has three primary outputs because its objective is to create a database of each output to analyze the response to the associated drug (insulin, propofol and sodium nitroprusside.
Bispectral Index	Every second during surgery	Depth of anesthesia will be measured by a Bispectral Index monitor.
Invasive blood pressure	Every 5 minutes during surgery

Trial Locations

Locations (1)

Unidad de Investigación Médica en Enfermedades Metabólicas IMSS; 🇲🇽 Mexico, Mexico City, Mexico