Development of a Methodology to Design a High Order Sliding Mode Controller for Drug Dosage
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Glucose
研究概览
简要总结
The aim of this observational study is to create a data base to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.
详细描述
The aim of this observational study is to create a database to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.
The observed drugs in this study are fast acting insulin, propofol and sodium nitroprusside.
The effect of insulin will be measured by a continuous glucose monitor, the effect of propofol by a bispectral index monitor and the the effect of sodium nitroprusside by a invasive blood pressure monitor.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) physical status I, II, II
排除标准
- •Impossibility to measure depth of anesthesia or invasive blood pressure. Impossibility of using glucose monitor.
结局指标
主要结局
Glucose
时间窗: Every 5 minutes during 3 days.
The glucose will be measured by a continuous glucose monitor. For the group of patients for diabetes. Note: This protocol has three primary outputs because its objective is to create a database of each output to analyze the response to the associated drug (insulin, propofol and sodium nitroprusside.
Bispectral Index
时间窗: Every second during surgery
Depth of anesthesia will be measured by a Bispectral Index monitor.
Invasive blood pressure
时间窗: Every 5 minutes during surgery
次要结局
未报告次要终点