Drug treatment of Laryngopharyngeal Reflux (LPR)
Completed
- Conditions
- aryngopharyngeal reflux (LPR)Digestive System
- Registration Number
- ISRCTN03482154
- Lead Sponsor
- niversity of Southampton (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 1500
Inclusion Criteria
All adult patients, aged 16 years and over referred from general practice to secondary care who following consultation with an Otolaryngological specialist have a working diagnosis for their symptoms of LPR
Exclusion Criteria
1. Children
2. Known or likely upper aerodigestive tract malignancy
3. Pregnancy
4. Known or suspected allergies to any medications used in the trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement in validated symptom scores using standardised validated questionnaires. Time points of measurement 2, 4 and 6 months
- Secondary Outcome Measures
Name Time Method 1. Laryngeal examination improvement (validated scoring system) at 2 and 6 months in a subgroup of patients<br>2. Physiological studies (pH / impedance) testing in a subgroup at 2 and 6 months<br>3. Tissue biopsy pre-treatment and at 2 and /or 6 months