COVID 19 Viral Clearance Among the Infected Healthcare Workers In Assiut University Hospitals

• Conditions: Infection, Coronavirus

• Registration Number: NCT04409574
• Lead Sponsor: Assiut University

Brief Summary

This work was aimed to determine the time of COVID 19 viral clearance in healthcare workers, assessment of clinical presentation and severity of COVID 19 infection among healthcare workers and discover relation between the time of COVID 19 viral clearance resolution of symptoms

Detailed Description

COVID-19 has been spreading rapidly globally, with a considerable impact on global morbidity, mortality and healthcare utilization. This viral disease is caused by the Coronaviruses (CoV) which belong to the genus'coronavirus' of the Coronaviridae family.

Coronaviruses are enveloped positive strand RNA viruses with the largest known RNA genomes-30-32 kb-with a 50 -cap structure and 30 -poly-A tail (Lei et al.2018). The transcription works through the replication-transcription complex (RCT) organized in double-membrane vesicles and via the synthesis of subgenomic RNAs (sgRNAs) sequences. Of note, transcription termination occurs at transcription regulatory sequences, located between the so-called open reading frames (ORFs). In the atypical CoV genome, at least six ORF scan could be present (Woo et al., 2020) .

Health workers are at the front line of the COVID-19 outbreak response and as such are exposed to hazards that put them at risk of infection (Li e al.,2020). thus keeping the implementation of infection prevention and control (IPC) and its knowledge and practice are of great importance in healthcare settings to protect them from infections (Wang et al., 2020).

Study Timeline

• Study First Submitted: 2020-05-28
• Study First Submitted QC: 2020-05-28
• Status Verified: 2020-06
• Study Start: 2020-06
• Study First Posted: 2020-06-01
• Last Update Submitted: 2020-06-01
• Last Update Posted: 2020-06-04
• Primary Completion: 2021-03
• Study Completion: 2021-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• Covid 19 infected healthcare workers.

Exclusion Criteria

• Risky healthcare workers (diabetic hypertensive and more than 50 years)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the time of Covid 19 viral clearance in medical healthcare workers and its relation to clinical presentation, severity among and resolution of symptoms.	basline	different relations between different symptoms, investigation results and time of viral clearness

Secondary Outcome Measures

Name	Time	Method
knowledge and practice of infection control measures	baseline	good and bad knowledge or practice