Correlation Between Portal and Splenic Venous Pulsatility Using Doppler Ultrasound as a Marker of Venous Congestion in Postoperative Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 主要终点
- Correlation between portal venous pulsatility index (portal PI) and splenic venous pulsatility index (splenic PI) measured by Doppler ultrasound.
研究概览
简要总结
Venous congestion is common in critically ill postoperative patients and may be associated with adverse outcomes. Doppler ultrasound assessment of venous flow patterns, including portal venous pulsatility, is increasingly used to evaluate systemic venous congestion.
This prospective observational study aims to determine the correlation between portal venous pulsatility and splenic venous pulsatility measured by Doppler ultrasound in adult patients admitted to a postoperative intensive care unit. The study will evaluate whether splenic venous pulsatility may provide additional information for the assessment of venous congestion.
Ultrasound examinations will be performed in addition to standard clinical care, without any therapeutic intervention or modification of patient management.
详细描述
Systemic venous congestion is increasingly recognized as an important pathophysiological factor in critically ill patients, particularly after major surgery. The Venous Excess Ultrasound (VExUS) grading system combines inferior vena cava assessment with Doppler evaluation of hepatic, portal, and renal venous flow patterns to identify clinically relevant venous congestion.
The portal venous pulsatility index (PI), calculated using pulsed-wave Doppler measurements at the hepatic hilum, has been described as a marker of venous congestion and has shown potential clinical relevance in the assessment of fluid status and decongestion response.
However, splenic venous pulsatility has not been systematically evaluated as a marker of venous congestion in critically ill patients, and its relationship with portal venous pulsatility remains unknown. Since both venous territories drain into the portal system and may reflect retrograde transmission of elevated right atrial pressure, splenic venous pulsatility could represent an additional non-invasive parameter for congestion assessment.
This prospective, observational, single-center study will investigate the correlation between portal and splenic venous pulsatility measured by Doppler ultrasound in postoperative critically ill patients. Secondary objectives include assessment of measurement reproducibility, evaluation of the relationship with VExUS grading, analysis in clinically relevant subgroups, and exploration of the association between splenic venous pulsatility and decongestion during ICU admission.
No experimental treatment will be administered, and all ultrasound assessments will be performed as an additional non-invasive evaluation alongside standard clinical management.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •nclusion Criteria:
- •Adults aged ≥18 years. Admission to the postoperative intensive care unit within 72 hours after surgery.
- •Adequate abdominal ultrasound window allowing visualization of the portal vein and splenic vein.
- •Written informed consent provided by the patient or legally authorized representative according to local regulations.
排除标准
- •Known chronic liver disease or previous portal hypertension. Previous pathological splenomegaly or prior splenectomy. Recent hepatic or splenic surgery during the same hospitalization. Known portal or splenic vein thrombosis. Absence of an adequate ultrasound window after two attempts by trained operators.
- •Death or discharge from the intensive care unit before completion of the first protocolized ultrasound assessment.
结局指标
主要结局
Correlation between portal venous pulsatility index (portal PI) and splenic venous pulsatility index (splenic PI) measured by Doppler ultrasound.
时间窗: Baseline assessment during the first 72 hours after admission to the postoperative intensive care unit.
The primary outcome is the degree of correlation between portal and splenic venous pulsatility indices assessed during the same ultrasound examination in postoperative critically ill patients.
次要结局
未报告次要终点
研究者
Lucia Valencia
Intensive Care Unit Attending Physician
Hospital Universitario de Gran Canaria Doctor Negrín