KCT0005038Completed未知
The comparative study of efficacy between different ilaprazole dose and administration period on contact granuloma caused by laryngopharyngeal reflux
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Enrollment
- 288
Study Overview
Brief Summary
There were significant dose- and duration-dependent differences in the efficacy of ilaprazole in patients with contact granuloma due to oropharyngeal reflux.
Study Design
- Study Type
- Interventional Study
Eligibility Criteria
- Ages
- 19(Year) to 75(Year) (—)
- Sex
- All
Inclusion Criteria
- •1) Patients over 19 year and below 75 year
- •2) Those who have reflux symptom index (RSI) more than 13 and reflux finding score (RFS) more than 7
- •3) Those with contact granuloma according to results of laryngoscope
- •4) Those who agree to participate in this clinical trial and sign voluntarily
- •5) Those who don’t have dementia or cognitive impairment
Exclusion Criteria
- •1) Those with the history of hypersensitivity reaction to proton pump inhibitor including ilaprazole
- •2) Those with need to take steroids or warfarin, coumarin, aspirin (more than 325mg/d) during this clinical trial constantly
- •3) Those with the history of administration with H2 receptor antagonists (H2RA), prostaglandin, protective agent of gastric mucosa, prokinetics, antiplatelet, and anticoagulants within 2 weeks or proton pump inhibitor (PPI) within 4 weeks from investigational drug administration
- •4) Those with the history of malignant tumor or surgery of the larynx
- •5) Those with observed preneoplastic lesions or neoplastic lesions in pharynx or larynx
- •6) Patients with zollinger-ellison syndrome, psychiatric patient, alcohol addictor or those with the history of drug abuse
- •7) Pregnant and lactating women
- •8) Childbearing women (Menopausal women who are amenorrheic for at least 12 months are considered to be non-childbearing women.)
- •9) Those who participated in other clinical trial within 6 months before screening
- •10) Those who are judged to be improper for this clinical trial
Investigators
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