on interventionel prospective study to develop a prognostic scoring system for outcome of autologous transplantation in multiple myeloma (MM).
Recruiting
- Conditions
- C90Multiple myeloma and malignant plasma cell neoplasms
- Registration Number
- DRKS00003964
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
MM-patients.
Exclusion Criteria
none
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The aim o the study is to prospectively validate a prognostic scoring sytem for<br>outcomes (EFS,OS) of autologous transplantation in Multiple Myeloma, developed<br>retrospectively at Hammersmith Hospital, London, based on tumour load at<br>diagnosis (Plasmacell% on trephine),cytogenetic aberrations (FISH and metaphase<br>cytogenetics) and treatment responses to chemotherapy prior to autologous<br>transplant.
- Secondary Outcome Measures
Name Time Method Test the predictive power of the score to identify a subgroup of high risk patients<br>who currently profit least from autologous stem cell transplantion and may be<br>candidates for therapeutic trials of novel agents.<br>Develop the prognostic score as a tool for such risk adapted therapies.<br>Validate the scoring sytem in patients treated with novel agents/drug combinations<br>Further definition of cytogenetic risk groups