Study of Thiamine Deficiency in Infants by Analysing Blood Sample Using Spectroscopic Technique
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- The primary outcome might help to detect thiamine deficiency in infants.
研究概览
简要总结
The gold standard method for detecting Thiamine deficiency is Liquid Chromatography-Mass Spectrometry (LC-MS), which is expensive and time consuming. So we are developing a technique based on HPLC combined with LED induced fluorescence for the detection of Thiamine deficiency in infants. The left over blood samples will be used for this study. Deficiency of thiamine can lead to lactic acidosis, which causes respiratory problem. So, we will be collecting blood sample from infants presenting with respiratory diseases as case. The Raman spectra of infantile blood will be recorded using the custom-built micro-Raman spectrometer for the comparison.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1.00 Month(s) 至 1.00 Year(s)（—）
- 性别
- All
入选标准
- •Control-Left over blood samples will be collected from healthy infants aged 1 month to 1 year.
- •Case- Left over blood samples will be collected from infants presenting with respiratory diseases, ranging in age from 1 month to 1 year.
排除标准
- •Control- All participants above 1 year old and having any health issues are excluded.
- •Case- All participants above 1 year old are excluded.
- •Babies with sepsis are also excluded.
结局指标
主要结局
The primary outcome might help to detect thiamine deficiency in infants.
时间窗: 2 years.
次要结局
- A cost-effective method for the detection of thiamine deficiency in infants.(3 years.)
研究者
Clint Mathew
Manipal Academy of Higher Education