Prospective Trial of Autologous Platelet Rich Plasma in Aortic Surgery
Not Applicable
Completed
- Conditions
- C.Surgical Procedure; Cardiac
- Interventions
- Device: Autologous Platelet-Rich Plasma Harvest Technique
- Registration Number
- NCT02513862
- Lead Sponsor
- Hongwen Ji
- Brief Summary
The purpose of this study is to determine whether autologous platelet rich plasma (APRP)is effective in reducing allogeneic blood transfusions during aortic surgery using deep hypothermic circulatory arrest.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- patients undergoing elective or emergency aortic surgery using deep hypothermic circulatory arrest、
- preoperative platelet counts>150000000000/L、
- preoperative hematocrit>33%、
- without recent anticoagulants less than 5 days
Exclusion Criteria
- preoperative coagulation disorder
- severe renal and liver dysfunction
- preoperative hemodynamic instability
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description APRP group Autologous Platelet-Rich Plasma Harvest Technique APRP group is performed autologous platelet-rich plasma harvest technique before administration of heparin to the patient,the red blood cell(RBC) component is retransfused to the patient when the RBC transfusion protocol is reached,and the autologous platelet-rich plasma is transfused to the patient immediately after heparin is neutralized with protamine.
- Primary Outcome Measures
Name Time Method total perioperative allogenic transfusions of platelet and fresh frozen plasma on the 7th day postoperatively
- Secondary Outcome Measures
Name Time Method rate of reexploration for bleeding on the 7th day postoperatively postoperative blood loss on the 7th day postoperatively
Trial Locations
- Locations (1)
Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC
🇨🇳Beijing, Beijing, China