Effect of Cannabis (Marijuana) on Stomach Emptying Before Surgery

Withdrawn

• Conditions: Gastric Emptying; Cannabis

• Registration Number: NCT05436236
• Lead Sponsor: The Guthrie Clinic

Brief Summary

The purpose of this research is to study the effect of cannabis (marijuana) on gastric (stomach) emptying before surgery. The study will include people who use cannabis (study group) and people who do not use cannabis (control group).

Detailed Description

About 108 people will take part in this study (54 in the study group and 54 in the control group). Subjects will have an ultrasound of the abdomen before their scheduled surgery. The ultrasound will determine how much fluid remains in the abdomen.

Researchers will also review subjects' medical records and will include: age, body mass index, history of cannabis use including how often and how consumed, reason for surgery, and length of time without eating before surgery.

Study Timeline

• Study First Submitted: 2022-06-23
• Study First Submitted QC: 2022-06-23
• Study First Posted: 2022-06-29
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-13
• Last Update Posted: 2024-02-14
• Study Start: 2024-12-01
• Primary Completion: 2025-12-01
• Study Completion: 2026-12-01

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Subjects 18 years and older
• Planned surgery at one of two hospitals within the healthcare system
• Willing to state if they use or do not use cannabis
• Able to read and consent on their own behalf

Exclusion Criteria

• Cognitively impaired
• Unable to read
• Children under the age of 18
• Pregnant women - Pregnancy status will be obtained from the routine pregnancy test performed prior to surgery
• History of gastroparesis
• Gastric surgeries
• Advanced liver or renal dysfunction
• Critically ill
• Emergent/urgent cases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gastric content volume	pre-operative	Gastric content volume as assessed by ultrasound prior to surgery

Secondary Outcome Measures

Name	Time	Method
Frequency of cannabis use	3 months prior to surgery	number of times per week patient uses cannabis
Cannabis use (chronic yes or no)	1 year prior to surgery	Yes or No for chronic cannabis use
Route of cannabis consumption	3 months prior to surgery	Categories of how cannabis is consumed (smoke, vape, other)
Time since last food; Nil per os (NPO) time	24 hours prior to surgery	Length of time patient had no food prior to surgery