Intrathecal Atropine Versus Preoperative Intravenous Ondasetron for Prevention of Postoperative Nausea and Vomiting Due to Intrathecal Morphine in Perineal Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- frequency of attacks of postoperative nausea and vomiting
研究概览
简要总结
To compare between intrathecal atropine versus preoperative administration of IV ondansetron in decreasing incidence of post operative nausea and vomiting related to intrathecal opioids in post operative period in perineal surgery as regard : efficacy and side effects .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between ( 18 - 45 ) years.
- •Body mass index between ( 18.5 - 35 )
- •patients undergoing perineal surgery as anal fissure , piles and rectocele
- •patients receiving bupivacaine ( 20 mg / 4 ml ) as spinal anesthesia
- •Patinets with physical status 1 or 2 according to ASA classification
排除标准
- •Patient refusal .
- •Any contraindication of neuraxial block as : coagulopathy , skin infection at injection site or bacteremia , hypovolemia and shock , history of allergy to L.A , sever aortic stenosis or mitral stenosis ......... etc
- •Patients with physical status other than 1 and 2 according to ASA classification
- •Those with history of nausea and vomiting , also those who received anti emetic drugs in last 2 hours of operation .
- •Allergy to any of the drug included in this study .
研究组 & 干预措施
patients receiving intrathecal atropine
Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% ) with morphine 250mic and atropine sulphate 100 micwith total volume = 2.5 ml .
干预措施: Ondansetron , atropine and bupivacaine (Drug)
patients receiving preoperative intravenous ondasetron
Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% with 0.5 ml normal saline with morphine 250 mic ) with total volume = 2.5 ml with giving 4 mg IV ondansetron before anesthesia ( patients with body weight more than 80 Kg may need additional 4 mg IV ) .
干预措施: Ondansetron , atropine and bupivacaine (Drug)
结局指标
主要结局
frequency of attacks of postoperative nausea and vomiting
时间窗: 6-9 months
Intrathecal atropine versus preoperative intravenous ondasetron for prevention of postoperative nausea and vomiting due to intrathecal morphine
次要结局
未报告次要终点
研究者
Shehab Mahmoud Mohamed
resident doctor at anesthesia and ICU department sohag university hospital
Sohag University