Comparison between immune response to different modes of vaccination; intradermal and subcutaneous yellow fever vaccination.
Completed
- Conditions
- (Prevention of) yellow fever.
- Registration Number
- NL-OMON27364
- Lead Sponsor
- eiden University Medical Center, dpt. of Infectious Diseases
- Brief Summary
PLoS ONE. 2008 Apr 23;3(4):e1993.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Healthy volunteers, >18yrs (previously and not previously vaccinated with yellow fever vaccine).
Exclusion Criteria
1. Pregnancy;
2. Diabetes mellitus;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Protective humoral immune response. <br /><br>For first time vaccinees measured 4 and 8 weeks post-vaccination, for revaccinees measured 2 weeks post-vaccination. <br /><br>All sera will be analysed by ELISA, Immunofluorescence and plaque reduction assay.
- Secondary Outcome Measures
Name Time Method Adverse events measured for three weeks post-vaccination by keeping a diary, viremia measured 5 days post-vaccination by RT-PCR.