Cerebral Protection in Aortic Arch Surgery

Aortic arch surgery is used to treat life-threatening aortic dissections, aortic aneurysms involving the arch and other aortic pathologies. The procedure is performed under deep hypothermic circulatory arrest. Neurological complications are detrimental and disabling for the patients, even if they survive. In the 1990s, the risk of stroke after aortic arch surgery was 48% with deep hypothermic circulatory arrest. The risk of stroke has largely decreased to about 3% after elective surgery and 11% after emergency aortic arch repair in recent years, largely attributed to the development of current cerebral protection strategies. Despite this, the risk of stroke is considerably high and it accompanies devastating disabilities for the patients leading to longer hospital stays and lower quality of life for surviving patients.

Neurological complications are not without an economic burden on the NHS healthcare system. After analysing 84,184 patients admitted to hospital with a stroke, it is reported that the mean total healthcare and social care cost of a stroke patient in the UK is £22,429 at 1 year, and this amount increases to £46,039 in 5-year. The costs also increase with age and severity of the stroke (Figure 1).

Electroencephalogram (EEG) and cerebral oximetry are currently used modalities for cerebral ischaemia monitoring, yet, they fail to detect early cerebral ischaemia. EEG only processes data from superficial cortex areas only. It is also affected by anaesthetic agents, neuromuscular blocking agents and other intraoperative factors. Cerebral oximetry uses near-infrared spectroscopy (NIRS) to monitor cerebral regional oxygen saturation in the frontal cortex. It has a weak predictive value of neurological events, and no data exists to support the optimum threshold of oximetry. Moreover, there is no association between spectroscopy measurements and stroke. The latest emerging imaging modality for monitoring is transcranial doppler ultrasound. It is operator-dependent and images are usually acquired through a small transtemporal window. It measures velocity in cranial arteries such as middle cerebral arteries, and it is still yet to be validated with larger studies. Limitations in these monitoring modalities could often bring the adequacy of cerebral protection into question.

The brain is a very sensitive organ to hypoxemia, and mixed venous oxygen saturation can be used to estimate the oxygen delivery and usage in the body by measuring the blood returning to the right side of the heart. Mixed venous saturation is influenced by many factors, such as cardiac output, respiration and oxygenation, and tissue metabolism in the perioperative period. Intraoperatively, it could serve as a more specific marker of global oxygen delivery during the cardiopulmonary bypass since the pump flow and metabolic rates are fairly constant.

Alternatively, certain proteins, such as the S100B protein, neuron-specific enolase and glial fibrillary protein (GFAP) could be monitored. They are released into the cerebrospinal fluid (CSF) and blood after cerebral damage. Their concentrations correlate with the extent of cerebral injury and predict the adverse clinical outcomes. However, S100B and neuron-specific enolase cannot accurately diagnose stroke, even after 6 hours from the onset of clinical symptoms. Moreover, their measurement results could take at least 2 hours, and also reliability of the measurements decrease with the use of cardiopulmonary bypass. Hence, their applicability in the hyperacute setting of aortic surgery is very limited.