The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed Oocytes
- Conditions
- Azoospermia, Nonobstructive
- Registration Number
- NCT03809026
- Lead Sponsor
- Odense University Hospital
- Brief Summary
Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are included. The women are stimulated with FSH in IVF protocols and the aspirated oocytes vitrified with usual applied techniques. Fresh sperm retrieved by micro-TESE are used for fertilization of the warmed oocytes. when it is not possible to obtain testicular sperm, the couples are offered fertilization with warmed oocytes.
Fertilization, cleavage, implantation and pregnancy rates using sperm from the patients versus from sperm donors will be compared.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Male
- Target Recruitment
- 100
Couples referred for micro-TESE
None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fertilization rate six years Measurement of % of fertilization among the warmed oocytes
Pregnancy rate six years Measurement of serum-hCG and ultrasonography at gestation age week 7
Cleavage rate six years Measurement of % of cleavage among the warmed oocytes
- Secondary Outcome Measures
Name Time Method Implantation rate six years Measurement of the % of transferred embryos implanting into the uterus
Trial Locations
- Locations (2)
Centre of Andrology & Fertility Clinic, Department D, Odense University Hospital
🇩🇰Odense, Denmark
Centre of Andrology & Fertility Clinic, Odense University Hospital
🇩🇰Odense, Denmark