The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed Oocytes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Fertilization rate
研究概览
简要总结
Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are included. The women are stimulated with FSH in IVF protocols and the aspirated oocytes vitrified with usual applied techniques. Fresh sperm retrieved by micro-TESE are used for fertilization of the warmed oocytes. when it is not possible to obtain testicular sperm, the couples are offered fertilization with warmed oocytes.
Fertilization, cleavage, implantation and pregnancy rates using sperm from the patients versus from sperm donors will be compared.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Couples referred for micro-TESE
排除标准
- 未提供
结局指标
主要结局
Fertilization rate
时间窗: six years
Measurement of % of fertilization among the warmed oocytes
Pregnancy rate
时间窗: six years
Measurement of serum-hCG and ultrasonography at gestation age week 7
Cleavage rate
时间窗: six years
Measurement of % of cleavage among the warmed oocytes
次要结局
- Implantation rate(six years)
研究者
Jens Fedder
Professor, MD, PhD
Odense University Hospital