A Prospective Evaluation of Polymer Based Fiducials for Use in Imaging Patients Receiving Treatment for Prostate Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Ultrasound versus MRI image fusion for daily prostate positioning
研究概览
简要总结
This trial is to determine if prostate target delineation obtained through an ultrasound based system is equivalent in accuracy to the MRI image fusion, and if alignment correction vectors obtained from ultrasound imaging are of equivalent accuracy to orthogonal X-ray imaging for daily prostate positioning.
详细描述
The investigators will also be assessing the following:
- Whether polymer-based markers can be adequately visualized on daily stereoscopic imaging compared to gold seed markers.
- Whether polymer-based markers are visible on ultrasound imaging.
- To determine if the polymer-based marker produces fewer artifacts on treatment planning CT scans than gold markers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed prostate adenocarcinoma
- •diagnosis of low risk or intermediate risk prostate cancer
- •approved for proton therapy treatment at CDH ProCure Proton Therapy Center
- •prescribed and consented for the placement of fiducial markers into the prostate as part of the standard treatment procedure
- •capable of receiving an MRI of the pelvis region for prostate localization
- •the prostate gland of eligible patients must be capable of imaging from an anterior trans-abdominal ultrasound as determined by the treating investigator
- •must be fluent in the English language; must be able to provide written study consent
排除标准
- •Evidence of a large TURP defect per investigator discretion
- •previous prostate cancer surgery including prostatectomy, hyperthermia and cryosurgery
- •previous pelvic radiation for prostate cancer
- •current grade 2 or above incontinence
- •history of orthopedic procedures in the area of the treatment, specifically no prior hip replacement or procedure in which metallic or high density material remains which would be within stereoscopic kilovoltage imaging area
- •prior permanent placement of any metallic or high density material within the prostate
- •known allergy to ultrasonic gel
结局指标
主要结局
Ultrasound versus MRI image fusion for daily prostate positioning
时间窗: 4 months
Determine if prostate target delineation obtained through an ultrasound based system is equivalent in accuracy to the MRI image fusion method, and if alighment crrection vectors obtained from ultransound imaging are of equivalent accuracy to orthogonal X-ray imaging for daily prostate positioning.
次要结局
- Polymer based marker visualization(4 months)
研究者
John Chang, MD
John Chang, MD
ProCure Proton Therapy Center