Exploring the role of thrombophilias in women with recurrent pregnancy loss and its treatment

Not Applicable

Completed

• Conditions: Recurrent miscarriage; Pregnancy and Childbirth

• Registration Number: ISRCTN64574169
• Lead Sponsor: Changhua Christian Hospital

Brief Summary

2016 results in https://pubmed.ncbi.nlm.nih.gov/27799851/ (added 30/11/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-19
• Study Completion: 2017-12-31
• Last Update Posted: 5 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 68

Inclusion Criteria

Part 1:
1. Women of child-bearing age
2. Recurrent pregnancy loss
3. Treated with heparin as part of standard care between 2011 and 2015

Part 2:
1. Women of child-bearing age
2. Recurrent pregnancy loss
3. Protein S deficiency (both the free antigen and function of protein S were reduced)

Exclusion Criteria

1. Allergic to heparin or other Low Molecular Weight Heparins
2. Problem with bruising or bleeding too easily
3. History of heparin-induced thrombocytopenia
4. Stroke
5. Recently had an operation on brain
6. Renal dysfunction

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ive birth rate is measured using the outcome of pregnancy at either abortion or live-births at the time of delivery collected from medical records.

Secondary Outcome Measures

Name	Time	Method
Obstetric complication rate is measured using specific parameters such as the birth body weight (if it is low birth weight for gestational age, or appropriate for gestational age), the gestational age when delivery (if less than 28 weeks, between 28 and 36 weeks of gestation, or term pregnancy meaning delivered later than 36 complete weeks of gestation) at delivery collected from medical records.