Evaluation of the Effect of Hypericum Perforatum L and Hyaluronic Acid on Excisional Palatal Wound Healing
- Conditions
- Wound Healing DisorderPalate; Wound
- Interventions
- Procedure: wound healing monitoringProcedure: Local application of hypericum perforatum L to the wound siteProcedure: local application of hyaluronic acid agent to the wound site
- Registration Number
- NCT06543199
- Lead Sponsor
- Ataturk University
- Brief Summary
The free gingival graft (FGG) procedure is one of the surgical approaches used to create a large area of adherent gingiva around the tooth and implant. As part of this procedure, one SDG at a time is harvested from the donor site of the secondary healing palate. The most common postoperative complications are pain, burning sensation and delayed wound healing at the donor site. Many agents have been used for years to reduce these complications, but so far none has been emphasized as the ideal agent. In this thesis, methods to improve the healing of the hard palate, the donor site for SDG surgery, and postoperative patient comfort will be compared.
- Detailed Description
The free gingival graft (FGG) procedure is one of the surgical approaches used to create a large adherent gingival and keratinized zone around teeth and implants. As part of this procedure, SDG is harvested from the palatal donor area. The most common postoperative complications from the palatal donor area left to secondary healing are pain, burning sensation and delayed wound healing at the donor site. Various hemostatic agents, dressing materials, platelet-rich fibrin and analgesics have been used for years to reduce postoperative complications, promote wound healing and increase patient comfort. However, none of them has been emphasized as the ideal agent in the relevant literature. In this thesis, we will compare the methods that will improve the healing of the hard palate, which is the donor site for SDG surgery, and postoperative patient comfort. Hypericum perforatum L and hyaluronic acid will be compared by local application to the palatal rotator area.
It is aimed to investigate the postoperative effects of topical application of Hypericum perforatum L and hyaluronic acid (trade names; HYPERICUM PERFORATUM L Dr Özberk St. John's wort oil; hyaluronic acid: Gengigel Forte Gel) on the healing of surgical wounds created in the palatal donor area after SDG and its effects on wound healing. Hyaluronic acid is a non-sulfated polysaccharide component of the glycosaminoglycan family, which is also found in joint fluids, serum and various body fluids such as saliva and gingival groove fluid. Although it is present in all periodontal tissues, it is especially prominent in non-mineralized tissues such as gingiva and periodontal ligament. The highly biocompatible and nonimmunogenic nature of the action of hyaluronic acid, its bacteriostatic, fungistatic, anti-inflammatory, antiedematous, osteoinductive and pro-angiogenetic properties leading to the promotion of wound healing in various tissues have led hyaluronic acid to be of interest in the treatment of various diseases in medical fields such as orthopedics, ophthalmology and dermatology. In dentistry, hyaluronic acid has been used in tooth extraction sockets, temporomandibular joint treatment to accelerate the healing process and to make the healing period comfortable.
Plants have always played an important role in the improvement of human health in history. Hypericum perforatum, a member of the Hypericaceae family, has been recognized as a valuable herbal medicine. This plant contains hyperforin, flavonoids and hypericin. The olive oil extract of H. perforatum has long been used as both topical and oral medicine to treat cuts, burns, depression, hemorrhoids, diabetes and gastrointestinal ulcers. Studies have shown that H. perforatum increases collagen deposition, shortens the duration of inflammation and stops the migration of fibroblasts during wound healing.
Both agents have many areas of use that have been tried and found to be effective on wound healing. It is aimed to contribute to the literature by evaluating these two agents in terms of wound healing and postoperative patient comfort in the palatal donor area and at the same time evaluating them with a control group in which no agent was used.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 45
- The patient is in need of free gingival graft (FGG) surgery,
- The patient's acceptance of the treatment,
- All oral plaque and bleeding scores less than 20%.
- Age between 18-60 years.
- The patient does not need SDG surgery,
- The patient is a smoker,
- The patient has a systemic disease that will affect recovery,
- The patient is unable to attend follow-up sessions,
- Previous periodontal surgery,
- The patient is pregnant or lactating,
- The patient has used antibiotics, corticosteroids, anti-inflammatory, immunosuppressive drugs in the last 6 months.
- Tooth deficiency such that the patient cannot wear acrylic aligners
- Acute periodontal condition
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description CONTROL wound healing monitoring Group in which no agent was used in the area left for secondary healing at the donor site. HYPERICUM PERFORATUM L wound healing monitoring Group using hypericum perforatum L agent in the area left for secondary healing at the donor site. HYPERICUM PERFORATUM L Local application of hypericum perforatum L to the wound site Group using hypericum perforatum L agent in the area left for secondary healing at the donor site. HYALURONIC ASID wound healing monitoring Group using hyaluronıc acid agent in the area left for secondary healing at the donor site. HYALURONIC ASID local application of hyaluronic acid agent to the wound site Group using hyaluronıc acid agent in the area left for secondary healing at the donor site.
- Primary Outcome Measures
Name Time Method assessment of pain at the donor site Days 1,2,3,4,4,5,6,7 Measuring and recording the pain score at the donor site with a vas
evaluation of chewing discomfort at the donor site Days 1,2,3,4,4,5,6,7 Measuring and recording the chewing discomfort score at the donor site with a vas
evaluation of burning in the donor area Days 1,2,3,4,4,5,6,7 Measuring and recording the burning score at the donor site with a vas
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tuğba Aydın
🇹🇷Erzurum, Hiçbiri seçilmedi, Turkey