Randomized, Controlled, Parallel Trial to Evaluate the Effects of Dihydrocapsiate on Energy Expenditure in Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 126
- 试验地点
- 1
- 主要终点
- Resting Energy Expenditure
研究概览
简要总结
The objective of this study is to test the effect of dihydrocapsiate on energy expenditure in women.
详细描述
Capsaicin, a substance found in chili pepper, is known to stimulate thermogenesis. Dihydrocapsiate, a capsinoid, found in the non-pungent CH-19 sweet pepper has similar thermogenic effects without the gastrointestinal side effects. The objective of this project is to test the effect of 12 weeks of daily consumption of 9 mg dihydrocapsiate on resting energy expenditure relative to baseline when compared to a control group consuming products without DCT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI: 18.5-34.5 kg/m2
- •Good general health
- •Low to mild physical activity
- •Willing to maintain habitual diet and physical activity patterns throughout the study period
- •Premenopausal and cycling regularly or using oral contraceptives
- •Willing to attend study visits only during the follicular phase or bleed phase of their menstrual cycle
- •Understands study procedures and signs forms providing informed consent to participate in the study
- •Have spoken and written English literacy
排除标准
- •Diabetes mellitus or any conditions that might affect energy metabolism
- •Weight change ±2 kg over previous three months
- •Known sensitivity or allergy to ingredients of the study products
- •Non-breakfast eater
- •Recent use of antibiotics
- •History of smoking during the six months prior to study
- •Recent signs or symptoms of infection, including cold or flu-like symptoms
- •Concurrent or recent intervention study participation
- •Instability in breathing patterns or energy expenditure measures
- •History of drug or alcohol abuse
- •Lipid-lowering, anti-hypertensive or anti-inflammatory steroid medication use
- •Weight loss medication
- •Pregnant or lactating
- •Unwilling to be randomized to any experimental group and unable to meet all requirements of the study
研究组 & 干预措施
Dihydrocapsiate 9 mg/d
9 mg/d of Dihydrocapsiate will be consumed in ready to ear cereal, cereal bars or crackers
干预措施: Dihydrocapsiate (Dietary Supplement)
Placebo 0 mg/d
0 mg/d of Dihydrocapsiate will be consumed in ready to ear cereal, cereal bars or crackers
干预措施: Dihydrocapsiate (Dietary Supplement)
结局指标
主要结局
Resting Energy Expenditure
时间窗: Change from Baseline at 12 weeks
次要结局
- Thermic effect of feeding(Change from baseline at 12 weeks)
- Body Composition(Change from baseline at 12 weeks)
研究者
Ellen Evans
Dr Ellen Evans
University of Georgia