NCT01472692已完成4 期
Treatment of Uric Acid With the Xanthine Oxidase Inhibitor Febuxostat: Effects on Blood Pressure, Metabolic Markers, and Aortic Stiffness in Prehypertensive
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Changes in 24 Hour Blood Pressure
研究概览
简要总结
High normal blood pressure, also called prehypertension, is a significant problem. High uric acid in the blood, the same thing that causes gout, may cause higher blood pressures. The investigators plan to monitor the effects of the drug febuxostat(trade name Uloric) on blood pressure and stiffness of the main blood vessels and see if lowering uric acid has any effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Prehypertensive male and female subjects with SBP =120-140 mmHg or DBP =80-90 mmHg (as determined by seated office BP).
- •Plasma uric acid level ≥5 mg/dl
- •Ages 18-50
- •non-smokers
- •Subjects will need to remain in the San Diego area for the duration of the study and be accessible by telephone or email.
排除标准
- •no current smoking in the prior 6 months.
- •Any history of any serious medical conditions requiring close monitoring from physicians- such as liver impairment, chronic kidney disease, or diabetes mellitus. Participants not currently under the care of a physician for these conditions will be eligible for the study.
- •Any history of gout, hypertension, hypercholesterolemia, morbid obesity.
- •Any history of use xanthine oxidase inhibitors, antihypertensives, antiglycemic, and cholesterol lowering medications
- •any history of illicit drug use within the last 6 months
研究组 & 干预措施
Febuxostat
Active Comparator
干预措施: Febuxostat (Drug)
Placebo
Placebo Comparator
干预措施: Febuxostat (Drug)
结局指标
主要结局
Changes in 24 Hour Blood Pressure
时间窗: 8 weeks
Changes in Pulse Wave Velocity
时间窗: 8 weeks
次要结局
未报告次要终点
研究者
研究点 (1)
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