NCT03125655RecruitingNot Applicable
Regulation of Inflammatory Genes in Psoriasis
University of Alabama at Birmingham2 sites in 1 country13 target enrollmentStarted: April 22, 2014Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 13
- Locations
- 2
- Primary Endpoint
- Inflammatory genes
Study Overview
Brief Summary
Psoriasis is a chronic and recurrent skin disorder characterized by marked inflammatory changes in the skin. An extensive cytokine network including generated by activated dendritic cells and T cells mediates the formation of psoriatic lesions. These immune-response parameters can be used as markers in the severity and management of the disease after further in-depth studies.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 19 Years to 99 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Clinical diagnosis of psoriasis
- •Must be age 19 or older.
- •Must be Fitzpatrick skin type I, II, III, IV, V, VI.
Exclusion Criteria
- •Subjects who do not have photosensitive disease and are not on photosensitizing medications.
- •Subjects with a history of keloids (who are more likely to develop hypertrophic scars following skin biopsy).
- •Subjects who have an allergy to local anesthetics, antibiotics and/or anticoagulants.
- •Subjects who are pregnant.
Outcomes
Primary Outcomes
Inflammatory genes
Time Frame: 1 day
TNF-alpha , IFN-alpha , IL-6, IL-8, IL-12 , IL-23, IL-4, IL-5 and IL-10
Secondary Outcomes
No secondary outcomes reported
Investigators
Nabiha Yusuf
Professor
University of Alabama at Birmingham
Study Sites (2)
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