Regulation of Inflammatory Genes in Psoriasis

Recruiting

• Conditions: Psoriasis; Inflammation

• Registration Number: NCT03125655
• Lead Sponsor: University of Alabama at Birmingham

Brief Summary

Psoriasis is a chronic and recurrent skin disorder characterized by marked inflammatory changes in the skin. An extensive cytokine network including generated by activated dendritic cells and T cells mediates the formation of psoriatic lesions. These immune-response parameters can be used as markers in the severity and management of the disease after further in-depth studies.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-04-22
• Study First Submitted: 2017-04-17
• Study First Submitted QC: 2017-04-19
• Study First Posted: 2017-04-24
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-26
• Last Update Posted: 2024-03-28
• Primary Completion: 2025-04-10
• Study Completion: 2027-04-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• Clinical diagnosis of psoriasis
• Must be age 19 or older.
• Must be Fitzpatrick skin type I, II, III, IV, V, VI.

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Exclusion Criteria

• Subjects who do not have photosensitive disease and are not on photosensitizing medications.
• Subjects with a history of keloids (who are more likely to develop hypertrophic scars following skin biopsy).
• Subjects who have an allergy to local anesthetics, antibiotics and/or anticoagulants.
• Subjects who are pregnant.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Inflammatory genes	1 day	TNF-alpha , IFN-alpha , IL-6, IL-8, IL-12 , IL-23, IL-4, IL-5 and IL-10

Trial Locations

Locations (1)

The Kirklin Clinic; 🇺🇸 Birmingham, Alabama, United States