Salivary Iron Level in Oral Lichen Planus Patients Undergoing Topical Corticosteroid Therapy
- Conditions
- OLP patients undergoing topical corticosteroid therapyoral lichen planus, topical corticosteroid, salivary iron, oral candidiasis
- Registration Number
- TCTR20220602006
- Lead Sponsor
- Faculty of Dentistry, Chulalongkorn University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 102
1. Healthy volunteers and OLP patients
2. OLP lesions with score 2, 3, 4 or 5 according to Thongprasom score
3. OLP lesions treated with 0.1%FAO for at least 1 month
4. OLP lesions with history of oral candidiasis reported from both
clinical appearance and laboratory report
5. No oral candidiasis on saliva collected date
6. No other autoimmune disease or uncontrolled diabetes mellitus,
hypothyroidism, hypoparathyroidism and hypoadrenocorticism or
medical conditions predisposing to oral candidiasis
7. No hematologic diseases
8. No history of blood donation or major blood loss for 4 months
before participate in the study
9. No severe periodontal disease
10. No wearing removable denture
11. No history of antifungal therapy for 2 weeks before participate in
the study
12. No taking iron supplement for 2 months before participate in the
study
13. No taking other systemic or local immunosuppressants
14. No smoking for 1 month before participate in the study
15. No menstruation on saliva collected date
1. Hyposalivation
2. Withdraw from the study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method salivary iron level 2 weeks after last subject ppm
- Secondary Outcome Measures
Name Time Method colony count of Candida in saliva 1 week after each subject logCFU/ml