COMPARATIVE EVALUATION OF PROPOFOL AND PROPOFOL WITH DEXMEDETOMIDINE FOR ATTENUATION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND INTUBATION.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- changes observed in vital parameters.
研究概览
简要总结
Endotracheal intubation is the translaryngeal placement of a tube into the trachea via the nose or mouth. This procedure includes laryngoscopy and intubation, the procedure is associated with intense sympathetic activity and hemodynamic stress marked by tachycardia, hypertension and sweating. Herein lays the rationale to continue the quest for an anaesthetic technique where the cardiovascular response can be attenuated. Various non-pharmacological and pharmacological methods have been used to attenuate the hemodynamic response to laryngoscopy and endotracheal intubation. Pharmacological methods like use of inhalational anaesthetic , topical lidocaine, narcotics, beta-blockers, calcium channel blockers, vasodilators have been tried. But none of the above approach and agents have proved to be ideal.so our primary outcome to know pressor response with dexmedetomidine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grade I and II scheduled for elective surgical procedures under general anaesthesia.
排除标准
- •Patients with anticipated difficult airway management ,hiatus hernia, GERD, BMI>30, patients on antihypertensive drugs, patients on sedatives, hypnotics , and antidepressants, H/o cardiovascular, respiratory, hepatic , renal diseases, patients with ASA grades III & above , endocrine disease and malnourished will be excluded from study.
结局指标
主要结局
changes observed in vital parameters.
时间窗: up to ten minutes.
次要结局
- side effects(during whole surgical time period)