Effects of Resveratrol on Cerebral Blood Flow Parameters and Cognitive Performance in Humans: a Double-blind, Placebo-controlled, Crossover Investigation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Modulation of Deoxygenated Levels of Haemoglobin
研究概览
简要总结
Research shows that resveratrol is able to induce vasodilation (and therefore blood flow) by interacting with nitric oxide (NO). Research also shows that acute administration of metabolic substrates, like oxygen and glucose, can enhance aspects of cognitive performance in young, healthy humans. The aim of this investigation was to determine if the consumption of resveratrol could modulate cerebral blood flow and if this in turn could influence cognitive performance by increasing access to blood borne metabolic fuel. Results showed that compared to placebo, after consuming 500mg pure trans-resveratrol, levels of total haemoglobin were significantly higher in the frontal cortex of young, healthy participants during cognitive task completion. Cognitive performance was not effected.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male/female,
- •Age 18-35 years old
- •Non smoker
- •Proficient in English
- •Not taking any herbal or prescription medications
- •Not pregnant
- •Does not drink more than 6 cups of coffee per day
排除标准
- •Suffered a head injury, neurological disorder or neuro-developmental disorder
- •Food allergies/intolerances
结局指标
主要结局
Modulation of Deoxygenated Levels of Haemoglobin
时间窗: 0-81 mins (absorption period=1- 45 mins , post dose period 46- 81 mins)
This outcome measure provides the change from baseline values (in µmol/L) of levels of deoxygenated haemoglobin during the 46-81 min post dose testing period. This was measured in the frontal cortex by near infrared spectroscopy (NIRS).
Modulation of Levels of Total Haemoglobin
时间窗: 0-81 mins (absorption period=1- 45 mins , post dose period 46- 81 mins)
This outcome measure provides the change from baseline values (in µmol/L) of total levels of haemoglobin during the 46-81 min post dose testing period. This was measured in the frontal cortex by near infrared spectroscopy (NIRS).
次要结局
- Number of Participants With Significant Modulation of Cognitive Performance(46-81 mins post dose)