ACTRN12607000301460
Completed
Phase 3
A randomised clinical trial to compare the efficacy of nebulized N-acetylcysteine and normal saline in improving sputum quality and diagnostic yield in patients with chest infections.
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Sputum quality, chest infections
- Sponsor
- Austin Health
- Enrollment
- 190
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Differential diagnosis inclusive of lower respiratory tract infection as determined by the treating physician (eg. cough, fever, pleuritic chest pain, dyspnoea, decreased breath sounds, bronchial breath sounds, crackles on auscultation) ·A sputum sample is to be collected in the ED.
Exclusion Criteria
- •Inability to co\-operate or consent due to debility, significant illness, language barriers, altered consciousness (as determined by the ED or study staff)·Refusal to participate·Pregnancy or breast\-feeding·Known allergy to NAC·Presence of significant hepatic or renal failure·Presence of other significant co\-morbidities eg. HIV, immunocompromised, cystic fibrosis, bronchiectasis·CXR suggestive of TB·Recent hospital admission within the previous 14 days inclusively·Current treatment with \>10mg prenisolone daily for more than 1 month inclusively
Outcomes
Primary Outcomes
Not specified
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