The effect of broccoli consumption on the activity of drug metabolising enzymes in people of European and South Asian ancestry
- Conditions
- Altered drug-metabolising enzyme activity (CYP1A2, CYP2C19, CYP2C9, CYP2D6 and CYP3A4) in people of European and South Asian ancestry.Other - Research that is not of generic health relevance and not applicable to specific health categories listed above
- Registration Number
- ACTRN12613001112752
- Lead Sponsor
- niversity of Sydney
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 12
i. Male, aged 18-55 years
ii. European or South Asian geographic ancestry
iii. Non-smoker or ex-smoker that has abstained from smoking for at least 6 months
iv. Ability to comply with the planned procedures and provide written informed consent
which requires a level of English language competency to effectively understand the
protocol and adequately meet the definition of informed consent
v. Self-reported healthy with no reported or diagnosed acute or chronic health conditions
vi. Access to a microwave with an appropriate cooking setting
i. Known hypersensitivity or intolerance to any of the five drugs used in the study
ii. History of clinical signs of hypotension, specifically fainting, light-headedness and/or a blood pressure lower than 80/60 mmHg
iii. Female
iv. Known food allergies or intolerances that limit participation in this study
v. Oral antimicrobial use within the past 3 months
vi. Body mass index (BMI) outside of 18.5-28.0 kg.m-2
vii. Currently taking or using any prescription, OTC, complementary or illicit medicines
viii. Recently given blood or recently involved in another clinical study in the last 3 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method