2023-506370-13-00招募中2 期
Involvement of the serotonergic system in the control of impulsivity in Tourette disorder : ARITEP
Hospices Civils De Lyon, Hospices Civils De Lyon1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2023年10月24日最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Correlation coefficients between changes in the binding potential (BPND) of [18F]-altanserin measured voxel-by-voxel in the whole brain and the evolution of scores BIS11 in TD patients.
研究概览
简要总结
To determine the correlative links between the availability of serotonergic 5-HT2A receptors and the variations in impulsivity measured in adults with Tourette's syndrome during treatment begin in the routine care.
研究设计
- 分配方式
- Not Applicable
- 主要目的
- Administration of a PET radiotracer
- 盲法
- None
入排标准
- 年龄范围
- 18 years 至 65+ years（18-64 Years, 65+ Years）
- 接受健康志愿者
- 否
入选标准
- •Male or Female
- •Diagnosed with a Tourette Disorder following the DSM-5
- •Age between 18-65 years
- •Member of a social security scheme in France
- •Freely-given informed consent to participate to this study (written form)
- •With a current treatment by aripiprazole already scheduled
- •With Tics compatible with TEP/fMRI exams
- •Having (for women only) effective contraception throughout participation in the study.
排除标准
- •Male or Female
- •A serious not controlled psychiatric comorbidity
- •A serious, evolving or debilitating pathology with a potential influence on the study
- •Drug-taking with serotonergic effects (e.g., amphetamine, cocaine, MDMA, SSRIs, mianserin)
- •Contraindication for fMRI and PET (e.g., pacemaker, ferromagnetic implant, claustrophobia)
- •Women breastfeeding
- •Protected or restricted person (administratively or in judicial terms)
- •Participants to another study with radiations or radiotracers since less of one year, participants to a concomitant study
- •Do not speak french
结局指标
主要结局
Correlation coefficients between changes in the binding potential (BPND) of [18F]-altanserin measured voxel-by-voxel in the whole brain and the evolution of scores BIS11 in TD patients.
Correlation coefficients between changes in the binding potential (BPND) of [18F]-altanserin measured voxel-by-voxel in the whole brain and the evolution of scores BIS11 in TD patients.
次要结局
- Correlation coefficients between changes in the binding potential (BPND) of [18F]-altanserin measured voxel-by-voxel in the whole brain and the evolution of other clinical scores and task performance of TD patients.
- Correlation coefficients between changes in the BOLD signal measured voxel-by-voxel in the whole brain and the evolution of scores BIS11 in TD patients.
- Correlation coefficients between changes in the BOLD signal measured voxel-by-voxel in the whole brain and the evolution of other clinical scores and task performance of TD patients.
研究者
Pr THOBOIS Stéphane
Scientific
Hospices Civils De Lyon
研究点 (1)
Loading locations...
相似试验
已完成
2 期
The possibility of 5-HIAA,serotonin metabolites, as a biomaker of depressed COPD patients.copd and depressionJPRN-UMIN000021326Tohoku university graduate school of medicine70
进行中（未招募）
1 期
Involvement of the serotonergic system in the control of impulsivity in Tourette disorder : ARITEPTourette disorderMedDRA version: 20.0Level: LLTClassification code: 10018271Term: Gilles de la Tourette's disorder Class: 10010331CTIS2023-506370-13-00Hospices Civils De Lyon20
招募中
不适用
Investigating the Neuropsychological Effects of 5-HT2a AntagonismNCT07022366University of Oxford80
Unknown
不适用
The role of 5-HT2 and 5-HT1A receptors in 3,4-methylenedioxymethamphetamine (MDMA) induced memory impairment and impulsivity.mdma users, cognition, 5HTNL-OMON23877WO18
已完成
2 期
Clinical Neurobiology of Serotonin and AddictionCocaine DependenceNCT00732901Virginia Commonwealth University160